I have added some new errata for Novus 2e this morning. This errata is about how Penalties are tracked and applied to characters.
Generic Penalties -- The only change here is a clarification that they only apply to skill rolls, never to Secondary Stats (which are used for Saves, Initiative, Defenseive Threshold, etc.).
Wound Penalties -- These apply to only to Secondary Stats. This means that they do apply to Saves, to Initiative, to Defensive Threshold, etc.
This means that there is no overlap to what the different penalties apply to.